Swine Cluster 1

Efficacy of feed additives to mitigate the negative impacts of mycotoxin contaminated feed on the performance and health of piglets

Project leaders


  • Frédéric Guay, Laval University, Québec, Québec
  • Martin Lessard, Agriculture and Agri-Food Canada (AAFC), Sherbrooke, Québec
  • Younès Chorfi, University of Montréal, Faculty of Veterinary Medecine, St-Hyacinthe, Québec


Project objective


Develop a protocol to evaluate the efficacy of feed additives available in Canada to attenuate the toxicity of naturally contaminated grains that may contain more than one mycotoxin and to mitigate the negative impact of mycotoxins on pig immune and intestinal functions.



Summary of the project


The project aims to develop quick indicators of mycotoxin exposure that allow early detection of mycotoxicosis in live animals by the way of a simple blood or urine sample. The effects of mycotoxin contaminated feeds on immune and vaccinal responses in weaned piglets will be evaluated together with an in vitro and in vivo study of the effects of mycotoxins on viral replication of PCV2 and PRRS in connection with the mycotoxin exposure. Researchers will also evaluate the effects of mycotoxin contaminated feeds on: 1) barrier integrity and function of the intestine, including digestive enzyme activities; 2) digestibility and retention of nutrients. Finally, a protocol will be developed to evaluate the efficacy of feed additives available in Canada to attenuate toxicity of naturally contaminated grains that may contain more than one mycotoxin and to mitigate the negative impact of mycotoxins on pig performances.


Significant achievements


Animal experimentation is underway in order to determine effects of vomitoxin (DON) contaminated feed on susceptibility to viral infections (circovirus, PRRSV) and on immune response in piglets. Furthermore, total of two (2) in vitro experiments were carried out by the University of Montreal research team. These experiments are precursors to the actual in vivo experiments. Another experiment began in September 2011 to assess the effect of DON and different “binder” of mycotoxins on digestion and nutrient retention in piglets. The experiment was conducted with five groups of 12 piglets and was completed in December 2011. So far, we have collected various blood, faeces and urine samples and note the different growth parameters (ADG, ADFI, G:F). Analyses of these samples began and the first results should be 

available in May 2012.

  

Associated documents


Mycotoxins and the Immune System - Newsletter November 2013